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	<title>Comments on: The MMR story that wasn&#8217;t</title>
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	<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/</link>
	<description>Ben Goldacre&#039;s Bad Science column from the Guardian and more...</description>
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		<title>By: diudiu</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-2/#comment-30190</link>
		<dc:creator>diudiu</dc:creator>
		<pubDate>Mon, 21 Dec 2009 05:48:05 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-30190</guid>
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		<title>By: Deano</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-2/#comment-14841</link>
		<dc:creator>Deano</dc:creator>
		<pubDate>Fri, 20 Jul 2007 08:12:28 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14841</guid>
		<description>igb wrote:

&quot;I’m too young (42) to recall the full details of the whooping cough saga of the 1970s: did that have the same general feel, or was there more basis to it?&quot;

- There was more basis to it.

Whooping Cough vaccine presented a small but real risk of brain injury to some children. However when whooping cough was prevelant, this was far outweighed by the risks of the disease itself.

As a result of this vaccine uptake was high, and Whopping Cough was almost eradicated.

At some point theoretically the risks of the vaccine to an individual then outweigh the risks of the disease.

An parent could choose to &#039;cheat&#039; the system - relying on &#039;herd immunity&#039; for their child&#039;s protection.

Of course if this selfishness spreads - then herd immunity will be compromised and there will be an outbreak amongst unvaccinated individuals.

Which despite all the warnings was exactly what happened - partly as a result of irresponsible media reporting by journalists who supported parents who were doing what was &quot;best for their children&quot;.

Totally in the spirit of those Thatcherite times of course

Newer vaccines have reduced side-effects - although the American Medical system conspires  against vaccination there, and there are unneccessary outbreaks - Worldwide about 300,000 kids die from it each year...

http://en.wikipedia.org/wiki/Pertussis#Whole-cell_pertussis_vaccine_controversy</description>
		<content:encoded><![CDATA[<p>igb wrote:</p>
<p>&#8220;I’m too young (42) to recall the full details of the whooping cough saga of the 1970s: did that have the same general feel, or was there more basis to it?&#8221;</p>
<p>- There was more basis to it.</p>
<p>Whooping Cough vaccine presented a small but real risk of brain injury to some children. However when whooping cough was prevelant, this was far outweighed by the risks of the disease itself.</p>
<p>As a result of this vaccine uptake was high, and Whopping Cough was almost eradicated.</p>
<p>At some point theoretically the risks of the vaccine to an individual then outweigh the risks of the disease.</p>
<p>An parent could choose to &#8216;cheat&#8217; the system &#8211; relying on &#8216;herd immunity&#8217; for their child&#8217;s protection.</p>
<p>Of course if this selfishness spreads &#8211; then herd immunity will be compromised and there will be an outbreak amongst unvaccinated individuals.</p>
<p>Which despite all the warnings was exactly what happened &#8211; partly as a result of irresponsible media reporting by journalists who supported parents who were doing what was &#8220;best for their children&#8221;.</p>
<p>Totally in the spirit of those Thatcherite times of course</p>
<p>Newer vaccines have reduced side-effects &#8211; although the American Medical system conspires  against vaccination there, and there are unneccessary outbreaks &#8211; Worldwide about 300,000 kids die from it each year&#8230;</p>
<p><a href="http://en.wikipedia.org/wiki/Pertussis#Whole-cell_pertussis_vaccine_controversy" rel="nofollow">http://en.wikipedia.org/wiki/Pertussis#Whole-cell_pertussis_vaccine_controversy</a></p>
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		<title>By: jackpt</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-2/#comment-14808</link>
		<dc:creator>jackpt</dc:creator>
		<pubDate>Thu, 19 Jul 2007 14:47:23 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14808</guid>
		<description>Well done Guardian.</description>
		<content:encoded><![CDATA[<p>Well done Guardian.</p>
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		<title>By: germslayer</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14807</link>
		<dc:creator>germslayer</dc:creator>
		<pubDate>Thu, 19 Jul 2007 13:21:30 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14807</guid>
		<description>Neil Desperandum (can&#039;t see comment no, sorry)

For Measles deaths look here:
http://www.hpa.org.uk/infections/topics_az/measles/nots_and_deaths.htm 

To quote:
&quot;In 2006 there was one measles death in a 13 years old male who had an underlying lung condition and was taking immunosuppressive drugs. Prior to 2006, the last death from acute measles was in 1992. Other measles deaths shown above are in older individuals and were caused by the late effects of measles. These infections were acquired during the 1980s or earlier, when epidemics of measles occurred.&quot;

I don&#039;t know when the scare started, but there have been small numbers of deaths throughout.</description>
		<content:encoded><![CDATA[<p>Neil Desperandum (can&#8217;t see comment no, sorry)</p>
<p>For Measles deaths look here:<br />
<a href="http://www.hpa.org.uk/infections/topics_az/measles/nots_and_deaths.htm" rel="nofollow">http://www.hpa.org.uk/infections/topics_az/measles/nots_and_deaths.htm</a> </p>
<p>To quote:<br />
&#8220;In 2006 there was one measles death in a 13 years old male who had an underlying lung condition and was taking immunosuppressive drugs. Prior to 2006, the last death from acute measles was in 1992. Other measles deaths shown above are in older individuals and were caused by the late effects of measles. These infections were acquired during the 1980s or earlier, when epidemics of measles occurred.&#8221;</p>
<p>I don&#8217;t know when the scare started, but there have been small numbers of deaths throughout.</p>
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		<title>By: gadgeezer</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14804</link>
		<dc:creator>gadgeezer</dc:creator>
		<pubDate>Thu, 19 Jul 2007 12:33:03 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14804</guid>
		<description>igb - &lt;a href=&quot;http://www.spiked-online.com/Articles/0000000CA6D2.htm&quot; rel=&quot;nofollow&quot;&gt;Dr Michael Fitzpatrick has written a good account of the whooping-cough debacle&lt;/a&gt;.

Brian Deer, of course, has an account of the matter that argues that the courts may well have got this one wrong when they awarded compensation for whooping cough vaccine damage.

The Intertubes are playing up so I can&#039;t verify this URL but I think that it is still correct.
http://briandeer.com/dtp-dpt-vaccine.htm</description>
		<content:encoded><![CDATA[<p>igb &#8211; <a href="http://www.spiked-online.com/Articles/0000000CA6D2.htm" rel="nofollow">Dr Michael Fitzpatrick has written a good account of the whooping-cough debacle</a>.</p>
<p>Brian Deer, of course, has an account of the matter that argues that the courts may well have got this one wrong when they awarded compensation for whooping cough vaccine damage.</p>
<p>The Intertubes are playing up so I can&#8217;t verify this URL but I think that it is still correct.<br />
<a href="http://briandeer.com/dtp-dpt-vaccine.htm" rel="nofollow">http://briandeer.com/dtp-dpt-vaccine.htm</a></p>
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		<title>By: used to be jdc</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14802</link>
		<dc:creator>used to be jdc</dc:creator>
		<pubDate>Thu, 19 Jul 2007 11:55:22 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14802</guid>
		<description>http://www.cdc.gov/vaccines/pubs/pinkbook/pink-chapters.htm has some lovely facts on vaccination, with free downloadable chapter pdfs (unfortunately you have to download measles, mumps and rubella separately - there is no triple pdf available). I went straight for the bit on orchitis.</description>
		<content:encoded><![CDATA[<p><a href="http://www.cdc.gov/vaccines/pubs/pinkbook/pink-chapters.htm" rel="nofollow">http://www.cdc.gov/vaccines/pubs/pinkbook/pink-chapters.htm</a> has some lovely facts on vaccination, with free downloadable chapter pdfs (unfortunately you have to download measles, mumps and rubella separately &#8211; there is no triple pdf available). I went straight for the bit on orchitis.</p>
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		<title>By: Gimpy</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14801</link>
		<dc:creator>Gimpy</dc:creator>
		<pubDate>Thu, 19 Jul 2007 11:05:54 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14801</guid>
		<description>muscleman, I know that it was very difficult to infect the animal models.  This could be because the animal models were a flawed representation of the disease, interspecies transfer is easier regarding prions between cows and humans than it is between mice and humans or that because transmission is so rare it is difficult to induce through feeding in a lab sized animal population, or any combination of the above.  
This is all besides the main point though that vCJD seems to be real (if thankfully incredibly rare) and the most likely explanation is prions in nervous tissue from BSE infected cows.  The link between human prions and CJD is indisputable and so is the link between bovine prions and BSE.  This is a wholly different situation from MMR/autism where there is no supporting evidence.</description>
		<content:encoded><![CDATA[<p>muscleman, I know that it was very difficult to infect the animal models.  This could be because the animal models were a flawed representation of the disease, interspecies transfer is easier regarding prions between cows and humans than it is between mice and humans or that because transmission is so rare it is difficult to induce through feeding in a lab sized animal population, or any combination of the above.<br />
This is all besides the main point though that vCJD seems to be real (if thankfully incredibly rare) and the most likely explanation is prions in nervous tissue from BSE infected cows.  The link between human prions and CJD is indisputable and so is the link between bovine prions and BSE.  This is a wholly different situation from MMR/autism where there is no supporting evidence.</p>
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		<title>By: stvb2170</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14799</link>
		<dc:creator>stvb2170</dc:creator>
		<pubDate>Thu, 19 Jul 2007 10:49:50 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14799</guid>
		<description>Is this the scientific equivalent of the sports pages &#039;bubble double&#039;. In the sport section a newspaper reports one day that a player is leaving his current team, leading with this story (often as an EXCLUSIVE). The next day they lead with the story that said player is staying. 

Did the Observer produce this Bad Science just so that you would be able to write about how bad it was the next week?</description>
		<content:encoded><![CDATA[<p>Is this the scientific equivalent of the sports pages &#8216;bubble double&#8217;. In the sport section a newspaper reports one day that a player is leaving his current team, leading with this story (often as an EXCLUSIVE). The next day they lead with the story that said player is staying. </p>
<p>Did the Observer produce this Bad Science just so that you would be able to write about how bad it was the next week?</p>
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		<title>By: muscleman</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14797</link>
		<dc:creator>muscleman</dc:creator>
		<pubDate>Thu, 19 Jul 2007 09:58:50 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14797</guid>
		<description>Gimpy, you should know that the animal models for CJD showed that attempting to get disease by feeding them &#039;affected&#039; material was extremely inefficient. Accordingly studies are routinely done by injecting material directly into the brain ventricles. 

vCJD also looks suspiciously like what you would get if you suddenly got funding etc to look much more closely at a population than you ever had before.</description>
		<content:encoded><![CDATA[<p>Gimpy, you should know that the animal models for CJD showed that attempting to get disease by feeding them &#8216;affected&#8217; material was extremely inefficient. Accordingly studies are routinely done by injecting material directly into the brain ventricles. </p>
<p>vCJD also looks suspiciously like what you would get if you suddenly got funding etc to look much more closely at a population than you ever had before.</p>
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		<title>By: nekomatic</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14796</link>
		<dc:creator>nekomatic</dc:creator>
		<pubDate>Thu, 19 Jul 2007 09:23:58 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14796</guid>
		<description>“New homes and schools should not be built within 60 metres of high voltage power lines until the link with childhood cancers is better understood by scientists, according to a committee of MPs.&quot;

Concern over health effects of high voltage power lines is not the same thing as concern over low frequency electromagnetic fields. There&#039;s a hypothesis that ionisation of the air by the high voltage can charge microscopic particles and make them more likely to enter people&#039;s lungs, for example. I have no idea what the current (sorry) consensus on that hypothesis is, but it doesn&#039;t involve a direct biological effect of the EM field.</description>
		<content:encoded><![CDATA[<p>“New homes and schools should not be built within 60 metres of high voltage power lines until the link with childhood cancers is better understood by scientists, according to a committee of MPs.&#8221;</p>
<p>Concern over health effects of high voltage power lines is not the same thing as concern over low frequency electromagnetic fields. There&#8217;s a hypothesis that ionisation of the air by the high voltage can charge microscopic particles and make them more likely to enter people&#8217;s lungs, for example. I have no idea what the current (sorry) consensus on that hypothesis is, but it doesn&#8217;t involve a direct biological effect of the EM field.</p>
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		<title>By: Gimpy</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14794</link>
		<dc:creator>Gimpy</dc:creator>
		<pubDate>Thu, 19 Jul 2007 07:26:20 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14794</guid>
		<description>igb @40

I do agree that it seems a lost of trust in science and government over health was a result of the BSE scare.  I was trying to show that at least some positives came out of BSE.  There are none yet for MMR.  Also, there was and is genuine concern regarding BSE/nvCJD, there is only falso concern regarding MMR/autism.  

I am considerably younger than you so was merely a twinkle in my mummys ovary for the 70&#039;s.  But I was talking to her about whooping cough the other day.  She thinks the scare was pretty much the same as the MMR thing and she knew many middle class flaky arts and humanities types who refused to get their children vaccinated with the result that several got whooping cough.</description>
		<content:encoded><![CDATA[<p>igb @40</p>
<p>I do agree that it seems a lost of trust in science and government over health was a result of the BSE scare.  I was trying to show that at least some positives came out of BSE.  There are none yet for MMR.  Also, there was and is genuine concern regarding BSE/nvCJD, there is only falso concern regarding MMR/autism.  </p>
<p>I am considerably younger than you so was merely a twinkle in my mummys ovary for the 70&#8217;s.  But I was talking to her about whooping cough the other day.  She thinks the scare was pretty much the same as the MMR thing and she knew many middle class flaky arts and humanities types who refused to get their children vaccinated with the result that several got whooping cough.</p>
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		<title>By: DaveF</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14792</link>
		<dc:creator>DaveF</dc:creator>
		<pubDate>Thu, 19 Jul 2007 01:27:18 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14792</guid>
		<description>Well done Ben - I don&#039;t suppose we&#039;ll know what negotiations you had to go thru with the Grauniad, but well done them in the end too.   I look forward to seeing your column as the front page lead in Sunday&#039;s Observer - that was what you were holding out for I trust.</description>
		<content:encoded><![CDATA[<p>Well done Ben &#8211; I don&#8217;t suppose we&#8217;ll know what negotiations you had to go thru with the Grauniad, but well done them in the end too.   I look forward to seeing your column as the front page lead in Sunday&#8217;s Observer &#8211; that was what you were holding out for I trust.</p>
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		<title>By: pv</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14791</link>
		<dc:creator>pv</dc:creator>
		<pubDate>Wed, 18 Jul 2007 23:43:24 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14791</guid>
		<description>igb @39
The press and broadcast news media are still the means by which the public en masse learn about any news. Unfortunately the means of communication is not benign and always carries an agenda or opinion of its own which has to be taken into account by those trying to get the message across. The government, scientists or whoever always have, unfortunately, to deal with what the press throw at them and it&#039;s hardly fair to blame them all the time. As many have pointed out, the current MMR scare is pretty much an invention of the press, obviously with a bit of help here and there. Although it&#039;s easy to criticize it&#039;s difficult to know what any government or anyone else can do in these circumstances. I feel the same was true over the BSE/vCJD affair. One could always with hindsight do things better, but one never has that benefit in the real world. If the press are determined to put a particular slant or spin on something there&#039;s nothing much you can do to stop them, short of introducing legislation. And I have to say here that it ill behoves anyone in the news media to criticize governments for &quot;spin&quot;. It&#039;s what the UK press do all the time, every day as a matter of routine. They call it news reporting.</description>
		<content:encoded><![CDATA[<p>igb @39<br />
The press and broadcast news media are still the means by which the public en masse learn about any news. Unfortunately the means of communication is not benign and always carries an agenda or opinion of its own which has to be taken into account by those trying to get the message across. The government, scientists or whoever always have, unfortunately, to deal with what the press throw at them and it&#8217;s hardly fair to blame them all the time. As many have pointed out, the current MMR scare is pretty much an invention of the press, obviously with a bit of help here and there. Although it&#8217;s easy to criticize it&#8217;s difficult to know what any government or anyone else can do in these circumstances. I feel the same was true over the BSE/vCJD affair. One could always with hindsight do things better, but one never has that benefit in the real world. If the press are determined to put a particular slant or spin on something there&#8217;s nothing much you can do to stop them, short of introducing legislation. And I have to say here that it ill behoves anyone in the news media to criticize governments for &#8220;spin&#8221;. It&#8217;s what the UK press do all the time, every day as a matter of routine. They call it news reporting.</p>
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		<title>By: igb</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14788</link>
		<dc:creator>igb</dc:creator>
		<pubDate>Wed, 18 Jul 2007 23:08:53 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14788</guid>
		<description>``The end result of the scare was better animal welfare, better quality processed meat and a better awareness of what makes good quality meat&#039;&#039;

And an absolutely massive mistrust by the general public of the pronouncements of both science and government on topics of controversy.   I can&#039;t offhand think of an event pre-BSE in which government and science looked quite so shifty and self-interested: the Windscale fire, perhaps.   And I can&#039;t see the MMR hoo-hah would have gained remotely as much traction as it did without the BSE wrangle.   The MPA page on MMR (http://www.hpa.org.uk/infections/topics_az/vaccination/071102_MMRpreferable.htm  ) explicitly makes the link.

I&#039;m too young (42) to recall the full details of the whooping cough saga of the 1970s: did that have the same general feel, or was there more basis to it?</description>
		<content:encoded><![CDATA[<p>&#8220;The end result of the scare was better animal welfare, better quality processed meat and a better awareness of what makes good quality meat&#8221;</p>
<p>And an absolutely massive mistrust by the general public of the pronouncements of both science and government on topics of controversy.   I can&#8217;t offhand think of an event pre-BSE in which government and science looked quite so shifty and self-interested: the Windscale fire, perhaps.   And I can&#8217;t see the MMR hoo-hah would have gained remotely as much traction as it did without the BSE wrangle.   The MPA page on MMR (<a href="http://www.hpa.org.uk/infections/topics_az/vaccination/071102_MMRpreferable.htm" rel="nofollow">http://www.hpa.org.uk/infections/topics_az/vaccination/071102_MMRpreferable.htm</a>  ) explicitly makes the link.</p>
<p>I&#8217;m too young (42) to recall the full details of the whooping cough saga of the 1970s: did that have the same general feel, or was there more basis to it?</p>
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		<title>By: Gimpy</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14787</link>
		<dc:creator>Gimpy</dc:creator>
		<pubDate>Wed, 18 Jul 2007 22:46:58 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14787</guid>
		<description>igb the difference between nvCJD and &#039;MMR causes autism&#039; is that animal models were developed that clearly showed neural degeneration as a result of cow prions in diet. 
http://www.springerlink.com/content/l74x00q787472164/
The link between prions and nvCJS is fairly indisputable whereas the link between MMR and autism is non-existent.  

Having said all that nvCJD seems to be a disease where only a tiny amount of genetically susceptible individuals are at risk of acquiring it.   Maybe the story was overblown but initially there really wasn&#039;t much research on the issue.  The end result of the scare was better animal welfare, better quality processed meat and a better awareness of what makes good quality meat in the consumer.  It is hard to identify any benefit from the MMR scare.</description>
		<content:encoded><![CDATA[<p>igb the difference between nvCJD and &#8216;MMR causes autism&#8217; is that animal models were developed that clearly showed neural degeneration as a result of cow prions in diet.<br />
<a href="http://www.springerlink.com/content/l74x00q787472164/" rel="nofollow">http://www.springerlink.com/content/l74&#215;00q787472164/</a><br />
The link between prions and nvCJS is fairly indisputable whereas the link between MMR and autism is non-existent.  </p>
<p>Having said all that nvCJD seems to be a disease where only a tiny amount of genetically susceptible individuals are at risk of acquiring it.   Maybe the story was overblown but initially there really wasn&#8217;t much research on the issue.  The end result of the scare was better animal welfare, better quality processed meat and a better awareness of what makes good quality meat in the consumer.  It is hard to identify any benefit from the MMR scare.</p>
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		<title>By: igb</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14785</link>
		<dc:creator>igb</dc:creator>
		<pubDate>Wed, 18 Jul 2007 22:18:37 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14785</guid>
		<description>&quot;suggesting we might be in for some more cases due to a long incubation period.&quot;

Well, the period of exposure is 1980 to 1990, roughly.  The exposure to beef is essentially the entire population, to nerve tissue probably slightly slanted towards younger and/or poorer.  There&#039;s been about 150 cases; that&#039;s perhaps three in a million of those exposed.  Those cases don&#039;t appear to have anything to identify them has being extensively exposed: some young, some veggie.  

The fringe / crank suggestion that vCJD was actually a symptom of organo-phosphate poisoning, say, is hard to exclude from a purely epidemiological perspective: I think I recall reading there was a slight bias towards non-urban areas.   The reality is that any epidemiology of a condition affecting 150-odd people over twenty years is going to be almost impossible to assess, unless they have some screamingly obvious common factor.  The prions themselves are slightly more visible than homeopathic `medicine&#039;, but as a causative agent the understanding is approximately zero.

To drag this back on topic: is the evidence for BSE causing vCJD any better than Wakefield&#039;s `evidence&#039; that MMR `causes&#039; autism?  Tiny numbers of cases extrapolated to large population-wide rates? Inexplicable mechanisms involving agents at the limits of detection, which differing labs are unable to replicate?  Mysterious disparity between the number of people exposed to the alleged agent and the number affected with the allegedly connected disease?  Claimed increases in conditions whose diagnosis is subtle and contentious?  Campaigns by distraught parents to fund increasingly surreal treatments?  It&#039;s all there, you know.</description>
		<content:encoded><![CDATA[<p>&#8220;suggesting we might be in for some more cases due to a long incubation period.&#8221;</p>
<p>Well, the period of exposure is 1980 to 1990, roughly.  The exposure to beef is essentially the entire population, to nerve tissue probably slightly slanted towards younger and/or poorer.  There&#8217;s been about 150 cases; that&#8217;s perhaps three in a million of those exposed.  Those cases don&#8217;t appear to have anything to identify them has being extensively exposed: some young, some veggie.  </p>
<p>The fringe / crank suggestion that vCJD was actually a symptom of organo-phosphate poisoning, say, is hard to exclude from a purely epidemiological perspective: I think I recall reading there was a slight bias towards non-urban areas.   The reality is that any epidemiology of a condition affecting 150-odd people over twenty years is going to be almost impossible to assess, unless they have some screamingly obvious common factor.  The prions themselves are slightly more visible than homeopathic `medicine&#8217;, but as a causative agent the understanding is approximately zero.</p>
<p>To drag this back on topic: is the evidence for BSE causing vCJD any better than Wakefield&#8217;s `evidence&#8217; that MMR `causes&#8217; autism?  Tiny numbers of cases extrapolated to large population-wide rates? Inexplicable mechanisms involving agents at the limits of detection, which differing labs are unable to replicate?  Mysterious disparity between the number of people exposed to the alleged agent and the number affected with the allegedly connected disease?  Claimed increases in conditions whose diagnosis is subtle and contentious?  Campaigns by distraught parents to fund increasingly surreal treatments?  It&#8217;s all there, you know.</p>
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		<title>By: BSM</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14783</link>
		<dc:creator>BSM</dc:creator>
		<pubDate>Wed, 18 Jul 2007 21:28:50 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14783</guid>
		<description>&quot;Seems that the only way that you get any sort of a proper apology from the media in this country is if you’re in your 80s and you wear a crown. Oh, and you have to be Queen too.&quot;

And that&#039;s another bloody funny thing.

I suppose we must accept that the trailer for that BBC programme was misleadingly edited, but she was in a snot about something and that seems not to have attracted any comment.

p.s. Forgot to add earlier: bloody excellent job Ben. The swearing is a triumph</description>
		<content:encoded><![CDATA[<p>&#8220;Seems that the only way that you get any sort of a proper apology from the media in this country is if you’re in your 80s and you wear a crown. Oh, and you have to be Queen too.&#8221;</p>
<p>And that&#8217;s another bloody funny thing.</p>
<p>I suppose we must accept that the trailer for that BBC programme was misleadingly edited, but she was in a snot about something and that seems not to have attracted any comment.</p>
<p>p.s. Forgot to add earlier: bloody excellent job Ben. The swearing is a triumph</p>
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		<title>By: RS</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14781</link>
		<dc:creator>RS</dc:creator>
		<pubDate>Wed, 18 Jul 2007 21:24:26 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14781</guid>
		<description>Not sure how gloves can fail to protect against vCJD prion proteins! Although you want to ensure you don&#039;t inhale the stuff.

There is an interesting hypothesis regarding vCJD, prion protein homo/heterozygosity derived from what happened with kuru and suggesting we might be in for some more cases due to a long incubation period.</description>
		<content:encoded><![CDATA[<p>Not sure how gloves can fail to protect against vCJD prion proteins! Although you want to ensure you don&#8217;t inhale the stuff.</p>
<p>There is an interesting hypothesis regarding vCJD, prion protein homo/heterozygosity derived from what happened with kuru and suggesting we might be in for some more cases due to a long incubation period.</p>
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		<title>By: IanWac</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14778</link>
		<dc:creator>IanWac</dc:creator>
		<pubDate>Wed, 18 Jul 2007 20:33:50 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14778</guid>
		<description>Nice article Ben.

Seems that the only way that you get any sort of a proper apology from the media in this country is if you&#039;re in your 80s and you wear a crown.  Oh, and you have to be Queen too.</description>
		<content:encoded><![CDATA[<p>Nice article Ben.</p>
<p>Seems that the only way that you get any sort of a proper apology from the media in this country is if you&#8217;re in your 80s and you wear a crown.  Oh, and you have to be Queen too.</p>
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		<title>By: simongates</title>
		<link>http://www.badscience.net/2007/07/the-mmr-story-that-wasnt/comment-page-1/#comment-14777</link>
		<dc:creator>simongates</dc:creator>
		<pubDate>Wed, 18 Jul 2007 20:16:36 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/?p=457#comment-14777</guid>
		<description>Something I don&#039;t think has been said is that even if the unpublished Cambridge paper did find a prevalence of 1 in 58 that may very well not provide any strong evidence that the prevalence was higher then expected because the confidence interval around a low prevalence like this will probably be quite wide.  I think I read somewhere that the sample size was actually 116 i.e. there were 2 autistic spectrum children. If this is right the 95% confidence interval around the estimate of 1.7% would be 0.5% to 6.0%, which includes pretty much every value that has ever been claimed.  So claiming an autism epidemic (let alone one caused by MMR) from these sorts of figures would be misleading even if the numbers were correct.</description>
		<content:encoded><![CDATA[<p>Something I don&#8217;t think has been said is that even if the unpublished Cambridge paper did find a prevalence of 1 in 58 that may very well not provide any strong evidence that the prevalence was higher then expected because the confidence interval around a low prevalence like this will probably be quite wide.  I think I read somewhere that the sample size was actually 116 i.e. there were 2 autistic spectrum children. If this is right the 95% confidence interval around the estimate of 1.7% would be 0.5% to 6.0%, which includes pretty much every value that has ever been claimed.  So claiming an autism epidemic (let alone one caused by MMR) from these sorts of figures would be misleading even if the numbers were correct.</p>
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