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	<title>Comments on: Part two of my Radio 4 show on the placebo effect, 9pm tonight (Monday)</title>
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	<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/</link>
	<description>Ben Goldacre&#039;s Bad Science column from the Guardian and more...</description>
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		<title>By: Robert Carnegie</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-22117</link>
		<dc:creator>Robert Carnegie</dc:creator>
		<pubDate>Thu, 11 Sep 2008 00:52:19 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-22117</guid>
		<description>Re 39: a placebo doesn&#039;t have to imitate a realistic non-placebo therapy except in the mind of the patient.  For instance, mumbo-jumbo with a crystal swung on a string over your body could be a placebo process.  And placebo isn&#039;t only relevant to  trials.  The placebo effect may be all that a patient needs to relieve, say, chronic back pain, psychologically at least: so why do anything else?  To avoid placebo side-effects perhaps - so we -do- need those trials.</description>
		<content:encoded><![CDATA[<p>Re 39: a placebo doesn&#8217;t have to imitate a realistic non-placebo therapy except in the mind of the patient.  For instance, mumbo-jumbo with a crystal swung on a string over your body could be a placebo process.  And placebo isn&#8217;t only relevant to  trials.  The placebo effect may be all that a patient needs to relieve, say, chronic back pain, psychologically at least: so why do anything else?  To avoid placebo side-effects perhaps &#8211; so we -do- need those trials.</p>
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		<title>By: BigEoinO</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-22089</link>
		<dc:creator>BigEoinO</dc:creator>
		<pubDate>Tue, 09 Sep 2008 14:07:50 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-22089</guid>
		<description>See the December BMJ for a quirky look at the requirements of evidence based science...

&quot;Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials&quot; 

link: 
http://www.bmj.com/cgi/content/full/327/7429/1459?ijkey=425457f110f8db584617b87a1eace92eaa39ff02</description>
		<content:encoded><![CDATA[<p>See the December BMJ for a quirky look at the requirements of evidence based science&#8230;</p>
<p>&#8220;Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials&#8221; </p>
<p>link:<br />
<a href="http://www.bmj.com/cgi/content/full/327/7429/1459?ijkey=425457f110f8db584617b87a1eace92eaa39ff02" rel="nofollow">http://www.bmj.com/cgi/content/full/327/7429/1459?ijkey=425457f110f8db584617b87a1eace92eaa39ff02</a></p>
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		<title>By: Getonyerbike</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-22072</link>
		<dc:creator>Getonyerbike</dc:creator>
		<pubDate>Mon, 08 Sep 2008 09:26:20 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-22072</guid>
		<description>A suggested definition to help:
Placebo: A intervention designed to mirror a trial intervention except for that aspect of the trial intervention under investigation. 

So for example in testing homeopathy to test whether the pills are active you would use the homeopathic consultation but with sugar pills. 

A placebo therefore can ONLY exist as a mirror intervention, it cannot exist in its own right. This helps clear the dillemna, &#039;what is a placebo effect?&#039; because instead we can say, &#039;what is the effect of sugar pills, or pink lights on a physiotherapy machine, or confident friendly consultation skills etc. i.e. calling these things what they are instead of lumping them under the catch-all, &#039;placebo&#039;

Additionally it can help doctors to be more aware of the complex way in which they are healers and not simply evidence-based prescribing machines.</description>
		<content:encoded><![CDATA[<p>A suggested definition to help:<br />
Placebo: A intervention designed to mirror a trial intervention except for that aspect of the trial intervention under investigation. </p>
<p>So for example in testing homeopathy to test whether the pills are active you would use the homeopathic consultation but with sugar pills. </p>
<p>A placebo therefore can ONLY exist as a mirror intervention, it cannot exist in its own right. This helps clear the dillemna, &#8216;what is a placebo effect?&#8217; because instead we can say, &#8216;what is the effect of sugar pills, or pink lights on a physiotherapy machine, or confident friendly consultation skills etc. i.e. calling these things what they are instead of lumping them under the catch-all, &#8216;placebo&#8217;</p>
<p>Additionally it can help doctors to be more aware of the complex way in which they are healers and not simply evidence-based prescribing machines.</p>
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		<title>By: Tony Sidaway</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-22069</link>
		<dc:creator>Tony Sidaway</dc:creator>
		<pubDate>Sun, 07 Sep 2008 17:33:23 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-22069</guid>
		<description>I accidentally listened to Radio 3 but it was still a fantastic programme.</description>
		<content:encoded><![CDATA[<p>I accidentally listened to Radio 3 but it was still a fantastic programme.</p>
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		<title>By: ips</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21955</link>
		<dc:creator>ips</dc:creator>
		<pubDate>Sun, 31 Aug 2008 20:28:01 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21955</guid>
		<description>Very interesting as usual . I am writing my MA project on &#039;Placebo&#039; (cultural aspects ...things like belief, role of religion and authority etc...) Dylan Evans has an interesting theory on placebo  called the &#039;acute phase response&#039; (you can download the pdf from his site). I like his idea that placebos largely &#039;work&#039; with &#039;defensive&#039; biological problems (this was Patrick Wall&#039;s opinion with pain interventions). Dylan looks at conditions such as depression/anxiety/pain and some types of inflammation as amenable to &#039;meaning responses&#039;(Dan Moremans idea) As these problems contribute to a considerable amount of suffering in general society than the factors that enhance placebo reactions are probably worthwhile studying and attempting to enhance in clinical practice.
For anyone that is interested Anne Harrington has a very interesting book out called the Cure Within - A History of Mind-Body Medicine which is relevant to the debate. 
ian</description>
		<content:encoded><![CDATA[<p>Very interesting as usual . I am writing my MA project on &#8216;Placebo&#8217; (cultural aspects &#8230;things like belief, role of religion and authority etc&#8230;) Dylan Evans has an interesting theory on placebo  called the &#8216;acute phase response&#8217; (you can download the pdf from his site). I like his idea that placebos largely &#8216;work&#8217; with &#8216;defensive&#8217; biological problems (this was Patrick Wall&#8217;s opinion with pain interventions). Dylan looks at conditions such as depression/anxiety/pain and some types of inflammation as amenable to &#8216;meaning responses&#8217;(Dan Moremans idea) As these problems contribute to a considerable amount of suffering in general society than the factors that enhance placebo reactions are probably worthwhile studying and attempting to enhance in clinical practice.<br />
For anyone that is interested Anne Harrington has a very interesting book out called the Cure Within &#8211; A History of Mind-Body Medicine which is relevant to the debate.<br />
ian</p>
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		<title>By: Robert Carnegie</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21938</link>
		<dc:creator>Robert Carnegie</dc:creator>
		<pubDate>Sun, 31 Aug 2008 01:13:51 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21938</guid>
		<description>Each alternate survey on the effect of mental attitude on cancer outcome reverses the previous published conclusion, turn about, it helps, it doesn&#039;t.  I don&#039;t think there&#039;s been one to say that being terrified and certain that you will die in agony improves the chance that you won&#039;t, it&#039;s positive thinking that is supposed to be the medicine.

I think we have discussed a psychology experiment where the perceived value of financial advice in an investment simulation depended on the price charged for the advice, or somethiing like that.  This probably maps to the abstract psychological element of placebo effect - someone is doing something nice for you - but that isn&#039;t necessarily the whole story.

Haere&#039;s a thought: placebo vaccine.  Bad iea, yes?</description>
		<content:encoded><![CDATA[<p>Each alternate survey on the effect of mental attitude on cancer outcome reverses the previous published conclusion, turn about, it helps, it doesn&#8217;t.  I don&#8217;t think there&#8217;s been one to say that being terrified and certain that you will die in agony improves the chance that you won&#8217;t, it&#8217;s positive thinking that is supposed to be the medicine.</p>
<p>I think we have discussed a psychology experiment where the perceived value of financial advice in an investment simulation depended on the price charged for the advice, or somethiing like that.  This probably maps to the abstract psychological element of placebo effect &#8211; someone is doing something nice for you &#8211; but that isn&#8217;t necessarily the whole story.</p>
<p>Haere&#8217;s a thought: placebo vaccine.  Bad iea, yes?</p>
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		<title>By: HypnoSynthesis</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21901</link>
		<dc:creator>HypnoSynthesis</dc:creator>
		<pubDate>Sat, 30 Aug 2008 09:43:22 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21901</guid>
		<description>&quot;A vivid imagination compels the body to obey it, for it is a natural principle of movement.  Imagination, indeed, governs all the forces of sensibility, while the latter, in its turn, controls the beating of the heart, and through it sets in motion all vital functions; thus the entire organism may be rapidly modified.  Nevertheless, however vivid the imagination, it cannot change the form of a hand or foot or other bodily member.&quot;  (Aristotle, cited by Coué, My Method, 1923: 4)

Autosuggestion, Coue stressed, does some things but not others.  It&#039;s sphere of effect is probably virtually the same as the placebo effect.  Stress, anxiety, pain, and depression seem to be particularly responsive to autosuggestion, and to some extent physical illness, which is sometimes exacerbated by stress.  As Coue long ago said, in his seminars,

&quot;For instance, if you have a leg cut off, and you imagine the leg will grow again, it is positive it will not grow again, because till now we are not able to produce such miracles; but if we have sad ideas, if we have organs which do not work well, if we have pain in a part of our body and we imagine that the sad ideas will be replaced by pink [sic.] ideas, that our organs will, little by little, function better; that the pain we have, in whatever part of the body, will disappear, it takes place, because it is possible.&quot;  (Coué, 1923: 111)</description>
		<content:encoded><![CDATA[<p>&#8220;A vivid imagination compels the body to obey it, for it is a natural principle of movement.  Imagination, indeed, governs all the forces of sensibility, while the latter, in its turn, controls the beating of the heart, and through it sets in motion all vital functions; thus the entire organism may be rapidly modified.  Nevertheless, however vivid the imagination, it cannot change the form of a hand or foot or other bodily member.&#8221;  (Aristotle, cited by Coué, My Method, 1923: 4)</p>
<p>Autosuggestion, Coue stressed, does some things but not others.  It&#8217;s sphere of effect is probably virtually the same as the placebo effect.  Stress, anxiety, pain, and depression seem to be particularly responsive to autosuggestion, and to some extent physical illness, which is sometimes exacerbated by stress.  As Coue long ago said, in his seminars,</p>
<p>&#8220;For instance, if you have a leg cut off, and you imagine the leg will grow again, it is positive it will not grow again, because till now we are not able to produce such miracles; but if we have sad ideas, if we have organs which do not work well, if we have pain in a part of our body and we imagine that the sad ideas will be replaced by pink [sic.] ideas, that our organs will, little by little, function better; that the pain we have, in whatever part of the body, will disappear, it takes place, because it is possible.&#8221;  (Coué, 1923: 111)</p>
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		<title>By: HypnoSynthesis</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21900</link>
		<dc:creator>HypnoSynthesis</dc:creator>
		<pubDate>Sat, 30 Aug 2008 09:36:44 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21900</guid>
		<description>There already is a non-deceptive placebo intervention, in a sense.  Various forms of psychological therapy which employ autosuggestion can be seen in this light.  Of course, hypnosis would be the most obvious example, although CBT (which evolved out of hypnotherapy in some respects) also employs self-talk as a means of self-regulating emotional responses which may have an effect upon physical health.

Now, as I mentioned in another post, as a hypnotherapist myself, even I would admit that it&#039;s accrued a great deal of flakeyness.  But the basic concept introduced by James Braid in the 1840s was dead simple...  If you help people to focus their attention for a while on a dominant idea, to the exclusion of anything else, and raise expectation, then there&#039;s an increased effect of the imagination upon the body&#039;s responses, and this can be used to deliberately (non-deceptively) replicate the placebo effect using suggestion.  Irving Kirsch therefore calls hypnosis a &quot;non-deceptive mega-placebo.&quot;

Proper research in the field of hypnosis, tends to suggest certain areas where it&#039;s more effective, and these can be compared to the sphere in which the placebo effect operates.

By the way, you should also consider Emile Coue in this respect.  He was the French pharmacist who popularised autosuggestion as a form of self-help in the 1920s.  He was very famous in his day.  I&#039;ll look for a snippet to post.</description>
		<content:encoded><![CDATA[<p>There already is a non-deceptive placebo intervention, in a sense.  Various forms of psychological therapy which employ autosuggestion can be seen in this light.  Of course, hypnosis would be the most obvious example, although CBT (which evolved out of hypnotherapy in some respects) also employs self-talk as a means of self-regulating emotional responses which may have an effect upon physical health.</p>
<p>Now, as I mentioned in another post, as a hypnotherapist myself, even I would admit that it&#8217;s accrued a great deal of flakeyness.  But the basic concept introduced by James Braid in the 1840s was dead simple&#8230;  If you help people to focus their attention for a while on a dominant idea, to the exclusion of anything else, and raise expectation, then there&#8217;s an increased effect of the imagination upon the body&#8217;s responses, and this can be used to deliberately (non-deceptively) replicate the placebo effect using suggestion.  Irving Kirsch therefore calls hypnosis a &#8220;non-deceptive mega-placebo.&#8221;</p>
<p>Proper research in the field of hypnosis, tends to suggest certain areas where it&#8217;s more effective, and these can be compared to the sphere in which the placebo effect operates.</p>
<p>By the way, you should also consider Emile Coue in this respect.  He was the French pharmacist who popularised autosuggestion as a form of self-help in the 1920s.  He was very famous in his day.  I&#8217;ll look for a snippet to post.</p>
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		<title>By: Getonyerbike</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21872</link>
		<dc:creator>Getonyerbike</dc:creator>
		<pubDate>Fri, 29 Aug 2008 16:45:57 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21872</guid>
		<description>hmm
i just tried using the phrase &quot;the published evidence doesn&#039;t support specialist referral because there is no evidence that it confers any benefit&quot;
and the patient said, &quot;i don&#039;t care!&quot;
The irony is that the specialist is keen for referrals despite the absence of evidence because that&#039;s how they get paid and the patient wants a referral because they don&#039;t believe that their problem could be of a self-limiting type that can resolve without a &#039;specialist&#039; intervention.
In this case the placebo is the &#039;specialist&#039; (being special)</description>
		<content:encoded><![CDATA[<p>hmm<br />
i just tried using the phrase &#8220;the published evidence doesn&#8217;t support specialist referral because there is no evidence that it confers any benefit&#8221;<br />
and the patient said, &#8220;i don&#8217;t care!&#8221;<br />
The irony is that the specialist is keen for referrals despite the absence of evidence because that&#8217;s how they get paid and the patient wants a referral because they don&#8217;t believe that their problem could be of a self-limiting type that can resolve without a &#8217;specialist&#8217; intervention.<br />
In this case the placebo is the &#8217;specialist&#8217; (being special)</p>
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		<title>By: Finny</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21868</link>
		<dc:creator>Finny</dc:creator>
		<pubDate>Fri, 29 Aug 2008 07:59:33 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21868</guid>
		<description>Ben

Off the thread I know, but related to your high BBC media profile.

Good chat on the breakfast sofa this morning on superfoods.

I&#039;m not sure how far rational persuasion is going to get on a programme where one of the main headlines is &#039;Line-up on Strictly Come Dancing announced&#039;.

Are Richard and Judy still going?</description>
		<content:encoded><![CDATA[<p>Ben</p>
<p>Off the thread I know, but related to your high BBC media profile.</p>
<p>Good chat on the breakfast sofa this morning on superfoods.</p>
<p>I&#8217;m not sure how far rational persuasion is going to get on a programme where one of the main headlines is &#8216;Line-up on Strictly Come Dancing announced&#8217;.</p>
<p>Are Richard and Judy still going?</p>
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		<title>By: Pro-reason</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21867</link>
		<dc:creator>Pro-reason</dc:creator>
		<pubDate>Fri, 29 Aug 2008 01:38:54 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21867</guid>
		<description>Lily, if you haven&#039;t yet installed the Vorbis codec, then here it is: http://www.vorbis.com/setup/  

MP3 is lower-quality, and patent-encumbered.

By the way, Ben, I thought you did a good job of grilling those doctors.  They all seemed to want to twist words to make out that they weren&#039;t lying to patients.  You were consistently open and frank about it.</description>
		<content:encoded><![CDATA[<p>Lily, if you haven&#8217;t yet installed the Vorbis codec, then here it is: <a href="http://www.vorbis.com/setup/" rel="nofollow">http://www.vorbis.com/setup/</a>  </p>
<p>MP3 is lower-quality, and patent-encumbered.</p>
<p>By the way, Ben, I thought you did a good job of grilling those doctors.  They all seemed to want to twist words to make out that they weren&#8217;t lying to patients.  You were consistently open and frank about it.</p>
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		<title>By: Getonyerbike</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21866</link>
		<dc:creator>Getonyerbike</dc:creator>
		<pubDate>Thu, 28 Aug 2008 17:13:58 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21866</guid>
		<description>Yes Lemonade, definately. A couple of centuries back in the philosophers believed that intelligent, reasoning sceptics had separate centers for emotion and reasoning but now scientists believe that the separation of reason and emotion is not only futile, but impossible. 

That said, there&#039;s a vast amount of ignorance about science and scientific method, statistical analysis and psychology that all contribute to the wonders of advertising, consumerism and new-age evangelicalism that rightly raise indignant heckles and Ben has to be cheered for trying to help us battle those who would exploit us with their false promises and dodgy marketing. 

We should be grateful that we&#039;re better educated, less anxious, less narcissistic (and hence less vulnerable to exploitation) than others, and do our (Christian) moral duty by protecting those who are.</description>
		<content:encoded><![CDATA[<p>Yes Lemonade, definately. A couple of centuries back in the philosophers believed that intelligent, reasoning sceptics had separate centers for emotion and reasoning but now scientists believe that the separation of reason and emotion is not only futile, but impossible. </p>
<p>That said, there&#8217;s a vast amount of ignorance about science and scientific method, statistical analysis and psychology that all contribute to the wonders of advertising, consumerism and new-age evangelicalism that rightly raise indignant heckles and Ben has to be cheered for trying to help us battle those who would exploit us with their false promises and dodgy marketing. </p>
<p>We should be grateful that we&#8217;re better educated, less anxious, less narcissistic (and hence less vulnerable to exploitation) than others, and do our (Christian) moral duty by protecting those who are.</p>
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		<title>By: Lemonade Lily</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21865</link>
		<dc:creator>Lemonade Lily</dc:creator>
		<pubDate>Thu, 28 Aug 2008 16:14:01 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21865</guid>
		<description>Thanks for mp3 JB - will now enjoy Placebo train journey tomorrow am.  Am not sure what to do with Oggs but they sound nice. 

Ian - agree - can intelligent, reasoning sceptics benefit from the placebo effect?</description>
		<content:encoded><![CDATA[<p>Thanks for mp3 JB &#8211; will now enjoy Placebo train journey tomorrow am.  Am not sure what to do with Oggs but they sound nice. </p>
<p>Ian &#8211; agree &#8211; can intelligent, reasoning sceptics benefit from the placebo effect?</p>
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		<title>By: Getonyerbike</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21864</link>
		<dc:creator>Getonyerbike</dc:creator>
		<pubDate>Thu, 28 Aug 2008 16:10:51 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21864</guid>
		<description>Does anyone know the effect of paying for treatment?

Has anyone done a trial for example, of paying Gillian Mckeith either nothing, a lot, or an awful lot for the same &#039;treatment&#039; and then measuring the outcome?

If paying more for a treatment makes it more effective, how do we determine which patient and which treatments are influenced (or not) by this?</description>
		<content:encoded><![CDATA[<p>Does anyone know the effect of paying for treatment?</p>
<p>Has anyone done a trial for example, of paying Gillian Mckeith either nothing, a lot, or an awful lot for the same &#8216;treatment&#8217; and then measuring the outcome?</p>
<p>If paying more for a treatment makes it more effective, how do we determine which patient and which treatments are influenced (or not) by this?</p>
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		<title>By: Pro-reason</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21861</link>
		<dc:creator>Pro-reason</dc:creator>
		<pubDate>Thu, 28 Aug 2008 14:16:49 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21861</guid>
		<description>25MB?  That&#039;s a bit much.  The size of the whole Realaudio stream is only 14MB.  There&#039;s no point trying to re-encode it at such a high bitrate.  You&#039;re trying to encode data that ain&#039;t there.

I&#039;ve re-encoded it as Ogg Vorbis, with a low, variable bitrate.  You can hear the compression, but it&#039;s worth it for the file size.  I could add a few MB and make it sound perfect.

Part 1 (8.42MB):
http://www.mediafire.com/?ujmodjjrmdb

Part 2 (8.45MB):
http://www.mediafire.com/?s7hhiwdgh0h</description>
		<content:encoded><![CDATA[<p>25MB?  That&#8217;s a bit much.  The size of the whole Realaudio stream is only 14MB.  There&#8217;s no point trying to re-encode it at such a high bitrate.  You&#8217;re trying to encode data that ain&#8217;t there.</p>
<p>I&#8217;ve re-encoded it as Ogg Vorbis, with a low, variable bitrate.  You can hear the compression, but it&#8217;s worth it for the file size.  I could add a few MB and make it sound perfect.</p>
<p>Part 1 (8.42MB):<br />
<a href="http://www.mediafire.com/?ujmodjjrmdb" rel="nofollow">http://www.mediafire.com/?ujmodjjrmdb</a></p>
<p>Part 2 (8.45MB):<br />
<a href="http://www.mediafire.com/?s7hhiwdgh0h" rel="nofollow">http://www.mediafire.com/?s7hhiwdgh0h</a></p>
]]></content:encoded>
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		<title>By: Getonyerbike</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21860</link>
		<dc:creator>Getonyerbike</dc:creator>
		<pubDate>Thu, 28 Aug 2008 13:29:39 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21860</guid>
		<description>Clearly placebo effects are limited, but if you have heart disease or cancer you won&#039;t recover with anti-hypertensives or chemotherapy alone; you need empathy, hope, motivation and encouragement -all apparently components of the &#039;placebo effect&#039;

What Ben&#039;s progammes have demonstrated is that placebo effects are real and complex and involve a patient expectation, the doctor&#039;s behaviour and social factors (and more)

Placebo effect is too simple a term to adequately describe this range of processes, so we/you/ Ben(!) need(s) urgently to develop the necessary lexicon so that when we say &#039;snake oil&#039; we&#039;re not talking about good communication skills.</description>
		<content:encoded><![CDATA[<p>Clearly placebo effects are limited, but if you have heart disease or cancer you won&#8217;t recover with anti-hypertensives or chemotherapy alone; you need empathy, hope, motivation and encouragement -all apparently components of the &#8216;placebo effect&#8217;</p>
<p>What Ben&#8217;s progammes have demonstrated is that placebo effects are real and complex and involve a patient expectation, the doctor&#8217;s behaviour and social factors (and more)</p>
<p>Placebo effect is too simple a term to adequately describe this range of processes, so we/you/ Ben(!) need(s) urgently to develop the necessary lexicon so that when we say &#8217;snake oil&#8217; we&#8217;re not talking about good communication skills.</p>
]]></content:encoded>
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	<item>
		<title>By: geehigh</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21859</link>
		<dc:creator>geehigh</dc:creator>
		<pubDate>Thu, 28 Aug 2008 13:08:03 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21859</guid>
		<description>Whoops that&#039;ll teach me to read the posts above before sticking my oar in. Anyway hope the link is useful.

Graham :)</description>
		<content:encoded><![CDATA[<p>Whoops that&#8217;ll teach me to read the posts above before sticking my oar in. Anyway hope the link is useful.</p>
<p>Graham <img src='http://www.badscience.net/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' /> </p>
]]></content:encoded>
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	<item>
		<title>By: geehigh</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21858</link>
		<dc:creator>geehigh</dc:creator>
		<pubDate>Thu, 28 Aug 2008 13:06:12 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21858</guid>
		<description>For those who need to use real media files, and are fed up with real player, an alternative is Real Alternative available from http://www.free-codecs.com/download/real_Alternative.htm

It works a treat and leaves no adverts or associated crud on your system. I&#039;m listening to part 2 of Ben&#039;s programme now and it works fine.

Cheers.

Graham.</description>
		<content:encoded><![CDATA[<p>For those who need to use real media files, and are fed up with real player, an alternative is Real Alternative available from <a href="http://www.free-codecs.com/download/real_Alternative.htm" rel="nofollow">http://www.free-codecs.com/download/real_Alternative.htm</a></p>
<p>It works a treat and leaves no adverts or associated crud on your system. I&#8217;m listening to part 2 of Ben&#8217;s programme now and it works fine.</p>
<p>Cheers.</p>
<p>Graham.</p>
]]></content:encoded>
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		<title>By: Ian</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21856</link>
		<dc:creator>Ian</dc:creator>
		<pubDate>Thu, 28 Aug 2008 11:23:52 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21856</guid>
		<description>I&#039;ve just listened to the 2nd program and what struck me was the bind a placebo puts a knowledgable patient in.... You&#039;ve had the placebo (and good doctor patient relations) and you havn&#039;t been able to persuade your body to respond, so it is all your fault that you are not getting better.....</description>
		<content:encoded><![CDATA[<p>I&#8217;ve just listened to the 2nd program and what struck me was the bind a placebo puts a knowledgable patient in&#8230;. You&#8217;ve had the placebo (and good doctor patient relations) and you havn&#8217;t been able to persuade your body to respond, so it is all your fault that you are not getting better&#8230;..</p>
]]></content:encoded>
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	<item>
		<title>By: Ian</title>
		<link>http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/comment-page-1/#comment-21855</link>
		<dc:creator>Ian</dc:creator>
		<pubDate>Thu, 28 Aug 2008 10:12:21 +0000</pubDate>
		<guid isPermaLink="false">http://www.badscience.net/2008/08/part-two-of-my-radio-4-show-on-the-placebo-effect/#comment-21855</guid>
		<description>thanks jb!!
but is mediafire always so slow - I know my connection is often slow but 6KB/sec??</description>
		<content:encoded><![CDATA[<p>thanks jb!!<br />
but is mediafire always so slow &#8211; I know my connection is often slow but 6KB/sec??</p>
]]></content:encoded>
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